Are leukotrienes involved in causing bronchial hyperresponsiveness?

Are leukotrienes involved in causing bronchial hyperresponsiveness?

Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways.

Among constitutively present cells, bronchoactive leukotrienes are produced predominantly by mast cells and macrophages. A unique characteristic of asthmatic inflammation is the migration of leukocytes from the peripheral blood to the conducting airways of the lung. This is especially true of the eosinophil, which is not present in the airways of normal individuals, but may be found in massiven...

Bronchial Hyperresponsiveness in Asthma*

Measurement ofnonspecific bronchial hyperresponsiveness remains largely a research tool in asthma, and its usefulness in the assessment and management of asthma is poorly defined. We StUdied the relationship of bronchial hyperresponsiveness to the clinical severity of asthma in 54 asthmatic subjects. In order to find out whether measurement of bronchial hyperresponsiveness could be used to pred...

Allergen-induced Bronchial Hyperresponsiveness

Bradykinin (BK) is a peptide mediator generated at sites of inflammation and its effects are mediated through constitutively expressed B 2 receptor or through induction of B 1 receptors. We examined the role of these receptors in bronchial hyperresponsiveness (BHR). Brown-Norway rats sensitized with ovalbumin (OA) and Al(OH) 3 intraperitoneally, were exposed 3 wk later to either saline or OA ae...

Resolution of Bronchial Hyperresponsiveness